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Hi Luis, I'm sure both Ted K and Miko B who own these type of devices can give you more detail, but it has been my experience that It won't have any effect on the sound of your guitar, with the exception that many of these systems require you to replace a neck pickup with the sustainer pickup. If you love that throaty sound of a strat neck pickup you might have to forgoe that sound for the sustainer. If I'm not mistaken, I think some of sustainers also respond like conventional pickups, but I know most people are pretty picky about sound and may not like the sound of the sustainer as pickup. I also know that with a little routing you could put your pickup and the sustainer pickup side by side in the neck cavity, thereby having your cake, and eating it too. Bill