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> i suppose the disadvantage of using the software mixer > compared to a hardware is not being able to mute the unused > channels quickly,i want to avoid at all cost having to grab > that damn mouse! This does not directly target your initial question (but onto that: no, I believe it is not possible), but I found that when I work with the computer, I need some kind of non-mouse-based user interface. This could be a kind of faderbox (and as usual, the starting point price-wise is something like a Behringer BCR2000 or BCF2000, both of which I'm happy with), or in a first step (if the application supports that) using your computer keyboard to do what you're after - this is possible e.g. in Ableton Live and would work for that specific application you're after. Rainer